Inheritable condition which accounts for part of a group of patients with idiopathic ventricular fibrillation who have no evidence of causative structural cardiac disease
Aetiology
12 associated genes - cardiac sodium and calcium channels
Autosomal dominant inheritance pattern
8x more likely in males
High incidence of the condition in Southeast Asian males
Pathophysiology
Risk factors for risk of arrhythmia
Rest or sleep
Fever
Excessive alcohol intake
Large meals
Dehydration
Electrolyte abnormalities
Drug triggers include anti-dysrhythmics e.g. flecainide, β-blockers, verapamil, antidepressants e.g. amitriptyline, analgesics, and anesthetics
Clinical features
Patients may be asymptomatic or present with palpitations and syncope due to arrhythmias such as AV nodal re-entrant tachycardias (AVNRTs), AF, polymorphic VT, or VF