Neurosensory disorder characterised by chronic MSK pain
Aetiology
Higher prevalence in women (6:1)
Commonest cause of MSK pain in women 22-50
May begin after emotional or physical trauma
May occur as a primary condition but is also seen in approximately 25% of patients with RA and approximately 50% of patients with SLE
There is often a familial predisposition, suggesting a genetic component
Pathophysiology
Current evidence suggests that it is part of a central nervous system (CNS) driven pain amplification syndrome, indicating a dysregulation of pain perception
Patients tend to have a lower threshold of pain and of other stimuli, such as heat, noise, and strong odours
Not associated with inflammation
Clinical presentation
Chronic (> 3 months), widespread body pain, often described as a constant dull ache
Pain/tenderness on both sides of the body, above and below the waist, and includes the axial spine
Fatigue - disrupted and unrefreshing sleep
Headaches
Cognitive disturbances, such as problems with focus and memory
Mood disorders, particularly depression and anxiety
