Aspirin

Main indications

• Anti-platelet agent

Mechanism of action

• Inhibits cyclo-oxygenase which is necessary to produce thromboxane A2 (a platelet agonist released from granules on activation)

Adverse effects

• Bleeding
  • Anti-platelet drugs tend to affect platelet function for their 7-10 day lifespan
  • Stop anti-platelet agents 7 days prior to elective operations
  • If serious bleeding - can reverse with platelet transfusion
• Blocks production of prostaglandins - GI ulceration, bronchospasm

Administration

• PO

Clopidogrel, prasugrel

Main indications

• Anti-platelet agent

Mechanism of action

• ADP receptor antagonists

Adverse effects

• Bleeding
  • Anti-platelet drugs tend to affect platelet function for their 7-10 day lifespan
  • Stop anti-platelet agents 7 days prior to elective operations
  • If serious bleeding - can reverse with platelet transfusion

Administration

• PO

Dipyridamole