A rapidly progressive infection resulting in extensive necrosis of superficial fascia and overlying subcutaneous fat that can develop into a life-threatening condition within hours
Aetiology
Aerobic and anaerobic, gram-positive and gram-negative bacteria are frequently isolated
Both monomicrobial and polymicrobial causes are common
Typically, the infection enters the body through a break in the skin such as a cut or burn
Risk factors
Poor immune function
Obesity
PWIDs
Peripheral arterial disease
Clinical features
Systemic symptoms - fever, chills, altered mental status
Diffuse erythema - often manifests initially as suspected cellulitis that is not responding to initial antibiotic therapy
Disproportionate pain
Crepitus
Purple skin discolouration
Investigations
Lab tests: can indicate infection through increased white blood cell count and inflammatory markers