SABA e.g. salbutamol

Main indications

• First line treatment for mild intermittent asthma
• COPD

Mechanism of action

• Agonists of β2-adrenoceptors
  • The sympathetic nervous system causes bronchodilation and decreases mucous secretion via β2-adrenoceptors

Contraindications and cautions

• Use with caution in patients with arrhythmias, CVD, diabetes, hypertension, hyperthyroidism, hypokalaemia and susceptibility to QT-interval prolongation

Adverse effects

• Tremor most common, can also affect heart rhythm

Administration

• Inhaler
• Spacer can be used to make inhalers easier to use (e.g. for children)

LABA e.g. beclomethasone

Main indications

• Nocturnal asthma - slow to act, last 8 hours
• COPD

Mechanism of action

• Agonists of β2-adrenoceptors
• Always administer with an ICS