Sepsis is defined as life-threatening organ dysfunction due to a dysregulated host response to infection

Aetiology

Risk factors

• Pre-natal invasive diagnostic procedures i.e. amniocentesis, CVS
• Cervical suture
• Prolonged rupture of membranes
• Operative delivery
• RPOC
• Diabetes
• Obesity
• Anaemia
• Immunosuppression

Sources of infection

Antenatal/intrapartum

• Chorioamnionitis
• GU including HSV
• Respiratory - influenza, COVID, CAP

Postnatal

• Endometritis +/- RPOC
• LUSCS wound/episiotomy